Use of metformin may improve overall survival in patients with T2D and breast cancer

Use of metformin may improve overall survival in patients with T2D and breast cancer...

Long-term use of metformin is associated with a decreased risk for colorectal cancer in men with diabetes, according to a study published in Cancer Epidemiology, Biomarkers & Prevention. Metformin is a drug approved by the U.S. Food and Drug Administration as a prescription medication to treat diabetes.

According to researchAssociation of Metformin with Breast Cancer Incidence and Mortality in Patients with Type II Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis” Preclinical data suggest that metformin may reduce breast cancer incidence and improve cancer prognosis. However, the current evidence in observational studies is inconclusive. A systematic review and meta-analysis was conducted to assess the effect of metformin on the incidence of breast cancer and all-cause mortality in patients with type II diabetes (T2D).

Grace H. Tang, Meloja Satkunam, Gregory R. Pond, Gregory R. Steinberg, Giovanni Blandino, Holger J. Schünemann and Paola Muti are researchers of this study.

A total of 12 observational studies were included for breast cancer incidence and 11 studies for all-cause mortality. No significant association was found between metformin exposure and incidence of breast cancer (OR = 0.93; 95% CI, 0.85–1.03; I2 = 35%). A 45% risk reduction was observed for all-cause mortality (HR = 0.55; 95% CI, 0.44–0.70; I2 = 81%). Presence of publication bias is strongly suspected for both outcomes using Egger's funnel plots.

Study concludes that The use of metformin may improve overall survival in patients with T2D and breast cancer. No effect of metformin on the incidence of breast cancer was observed. Interpretation of results is limited by the observational nature of the studies and resulting biases.

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